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How do phospholipids give the cell membrane the self-sealing property?

How do phospholipids give the cell membrane self-sealing property?
Original post by Biochemistry - Berg JM, Tymoczko JL, Stryer L.New York: W H Freeman

Because lipid bilayers are held together by many reinforcing, noncovalent interactions (predominantly hydrophobic), they are cooperative structures. These hydrophobic interactions have three significant biological consequences: (1) lipid bilayers have an inherent tendency to be extensive; (2) lipid bilayers will tend to close on themselves so that there are no edges with exposed hydrocarbon chains, and so they form compartments; and (3) lipid bilayers are self-sealing because a hole in a bilayer is energetically unfavorable.

See above
Reply 2
Original post by SANTR
How do phospholipids give the cell membrane self-sealing property?


Is it because they have a hydrophobic and hydrophillic end? So this means the molecules arrange themselves and form a bilayer, which gives the cell membrane the self-sealing property.

(roughly I think)
Reply 3
Original post by keromedic
See above


Ok thanks.
Do you know why water soluble substance cannot pass through the cell surface membrane?
Original post by SANTR
Ok thanks.
Do you know why water soluble substance cannot pass through the cell surface membrane?


Because of the hydrophobic core, the layer is not permeable to large polar molecules.
Reply 5
Original post by keromedic
Because of the hydrophobic core, the layer is not permeable to large polar molecules.


Is this because the hydrophobic tails repel the polar molecules?
Original post by SANTR
Is this because the hydrophobic tails repel the polar molecules?


Yes :yy:.

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