Unless there's something intrinsic about a character that's tied to their gender or some other key characteristic, I really don't care as long as they make a good movie. For example James Bond is a quintessentially male character and quintessentially english, but I wouldn't care if somebody of a different race was cast as long as it was still a well portrayed Bond in a well made Bond film. In the same vein there is nothing necessarily male about the Ghostbusters concept and Doctor Who is a shape changing alien, if they want to do a female interpretation of them and they do it well, I've got no issues. Nothing about these interpretations is inherently doomed.
The problem with both Ghostbusters and Doctor Who is that they are both badly put together pieces of television/film. Ghostbusters was a mediocre mess that tried to use its all-female gimmick as a crutch for a crap story and cringeworthy comedy, while Doctor Who has suffered from sh*t writing for years now. Oceans 8 was the exact same thing too, despite Widows coming out the same year and doing an all-female heist film really well.