why do enzymes need to be water soluble?

they are water soluble bc polar amino acids are on the outside of the tertiary structure and non-polar on the inside but WHY is this importnat?

Like you said enzymes have polar amino acids on the outside and non-polar on the inside, so they are shaped like a ball meaning they are globular proteins. So in water, polar amino acids on the outside form hydrogen bonds with water molecules. This basically means enzymes dissolve in water and are able to catalyse whatever reaction they need to catalyse

Hi,

I just thought it would be an important reminder that proteins such as hormones and enzymes need to be soluble so they can be transported where they are needed.To ensure that they are soluble, they must be polar on the outside so they can effectively form hydrogen bonds.

You probably already know this.
GL
-Frustrated Horse