I notice no effect from antidepressants as my depression is, I think, connected to nihilism. I don't see the point of existence, and rationally there doesn't appear to be a good explanation. For me, I think the best cure is to try and find some temporary goal and to fill your life with stories. Is clinical depression the same as this? People always diagnose me with depression and anxiety, but I think the issue stems from existential angst and awareness.
Sometimes I feel suicidal; at other times I feel curious and want to enjoy the world we have.