Provided you have the core subjects (maths, English Lang, English Lit etc), no, universities don't really care what you took - the one exception to this is that UCL wants you to take a modern foreign language. In terms of science, I'd recommend (if you're capable of it) you take triple science, or double science if that's what your school offers, because taking single science often means that you can't take science subjects beyond GCSE. Just leave your options open - take a humanity (geography, history or RE), take a modern language, take an arts-related subject (drama, art or DT) and you'll be fine, but above all do subjects you genuinely enjoy and are good at.