Don't know how you apply with the new curriculum as it's changed since last year when I applied. For me I got 1 A* 5A 3B C for my GCSEs, at AS I got AAAAA. The only uni I got an interview from was Leeds, as they looked at AS or GCSE (whichever was better), not both. I unfortunately didn't get an offer but that was down to my interview performance, I was ranked 1/10 for grades (1 being the best, 10 the worst), and 5 on BMAT with a below average score. It's about applying smart. If you do exceptionall well in UKCAT you would probably get an interview from Newcastle.
This is presuming that you use your internal grades to put on UCAS but can't be certain as I'm unaware, hoped this helped