Have Evra, Wes, Rio and Gary at the back, Ronaldo, Scholes, O'Shea and Richardson in the middle, with Rooney and Saha up front. Bit too soon to use Smith in a big game from the start.
Alternatively have a middle 3 of Carrick, Scholes and Richardson, with Ronaldo, Rooney and Saha up front.
It'll be a close game I'd imagine, 2-1 United.