depends of how competitive the specific subject you are applying to is
if you have an A* overall and meet the basic requirements, you can still give it a shot - nothing to lose
only thing is applications were extremely competitive this year and may be the next year as well due to covid and other factors
I've heard of gold medal olympiad winners getting rejected and oxbridge demanding further maths for medicine...
but don't let that put you off; if you think you satisfied the requirements, wrote an excellent personal statement, and performed well on any preinterview tests, written work, etc., you maybe shortlisted for interview
impress them overall and you might get in
oh and there is always extenuating circumstances that you can mention...