dissertation topic

hi,

can someone find me four qualitative studies on sepsis or cancer or cardiovascular disease or endometriosis and formulate a question for the topic chosen.

Thank you.

Reply 1

Pro Researcher

I can take care of this and formulate the research question. do you still need it please?

Reply 2

macpatgh-Sheldon

Good afternoon young lady/man,

"Replacement of defective cardiac valves can be undertaken using novel endovascular techniques ["keyhole surgery"] or by open heart surgery, depending on various clinical criteria. With increasing pressure on doctors to allow patients to make decisions on their healthcare choices, is it fair to place the burden of such a complex decision on the shoulders of lay members of the public?

Refs
1. OBJECTIVES: This study sought to compare, in high-risk patients with 3+ to 4+ mitral regurgitation (MR) dichotomized by baseline echocardiographic features, acute, 30-day, and 12-month outcomes following percutaneous mitral valve repair using the MitraClip. BACKGROUND: The feasibility and mid-term outcomes after MitraClip implantation in patients with echocardiographic features different from the EVEREST (Endovascular Valve Edge-to-Edge Repair) I and II trials have been scarcely studied. METHODS: Clinical and echocardiographic outcomes through 12-month follow-up of consecutive patients who underwent MitraClip implantation were obtained from an ongoing prospective registry. Two different groups, divided according to baseline echocardiographic criteria (investigational group [EVERESTOFF] and control group [EVERESTON]), were compared. RESULTS: Seventy-eight patients were included in EVERESTOFF and 93 patients in EVERESTON groups. Important and comparable acute reductions in MR and no clip-related complications were revealed. The primary safety endpoint at 30 days was comparable between groups (2.6% vs. 6.5%, respectively, p = 0.204); in addition, MR reduction was mostly sustained, whereas equivalent improvement in New York Heart Association functional class were demonstrated. Kaplan-Meier freedom from death, surgery for mitral valve dysfunction, or grade >/=3+ MR at 12 months was demonstrated in 71.4% and 76.2%, respectively, in the EVERESTOFF and EVERESTON groups (log rank p = 0.378). Significant improvements in ejection fraction and reduction in left ventricle volumes were demonstrated in both groups over time, but the baseline between-group differences were sustained. CONCLUSIONS: MitraClip implantation in patients with expanded baseline echocardiographic features, compared with the control group, was associated with similar rates of safety and efficacy through 12-month follow-up. Further validation of our findings is warranted.

ATTIZZANI, G. F., OHNO, Y., CAPODANNO, D., CANNATA, S., DIPASQUA, F., IMME, S., MANGIAFICO, S., BARBANTI, M., MINISTERI, M., CAGEGGI, A., PISTRITTO, A. M., GIAQUINTA, S., FARRUGGIO, S., CHIARANDA, M., RONSIVALLE, G., SCHNELL, A., SCANDURA, S., TAMBURINO, C., CAPRANZANO, P. & GRASSO, C. 2015. Extended use of percutaneous edge-to-edge mitral valve repair beyond EVEREST (Endovascular Valve Edge-to-Edge Repair) criteria: 30-day and 12-month clinical and echocardiographic outcomes from the GRASP (Getting Reduction of Mitral Insufficiency by Percutaneous Clip Implantation) registry. JACC Cardiovasc Interv, 8, 74-82

2. BACKGROUND: Treatment of newborns with univentricular hemodynamics in combination with an anomaly of pulmonary venous return has the worst correction results in modern cardiac surgical papers. According to the data obtained by different authors, postoperative mortality in this cohort of patients varies from 41.7 to 53%. The presence of the venous outflow tract obstruction, as well as the serious condition of a newborn, is one of the main factors that increase the risk of death in the postoperative period. CASE PRESENTATION: This article reveals a clinical case of a patient with a combined heart disease prenatally diagnosed in the form of a functionally single ventricle with a double outlet of the main vessels from it, mitral valve atresia, an intact atrial septum and an anomaly of venous return, when the blood outflow from the left atrium was carried out through a single fetal communication such as stenotic cardinal vein. In order to stabilize the patient's condition, the newborn urgently underwent stenting of the stenotic section of the cardinal vein. However, due to the lack of positive dynamics in the postoperative period, the child underwent repeated endovascular intervention and stenting of the intraoperatively created interatrial communication was performed. Taking into account the absence of obstruction of the outflow tract to the pulmonary artery, it was necessary to perform an open surgical intervention in a short time such as pulmonary artery banding. CONCLUSIONS: Thus, palliative endovascular intervention in critically ill neonates with univentricular hemodynamics and anomalous pulmonary venous return can be considered as a method of choice that can become a new safer strategy for managing infants in order to stabilize the condition before the main stage of surgical intervention comes.

ARTEM, G., DENIS, M., ALINA, I., IGOR, A., DMITRIY, Z., ALEKSEI, P., ILYA, S., EVGENIY, G. & MIKHAIL, C. 2023. A clinical case of successful palliative endovascular treatment of a patient with a single ventricle, mitral valve atresia, an intact atrial septum and persistent cardinal vein. Egypt Heart J, 75, 41.

Here is a Q and two sample refs for you to start up your quest. The refs are formatted in line with the Harvard style [pls use the style stipulated by your school/college - you can use Endnote if your sch library has it or you can use a free Ref Management package like Zotero].

Good sites for searchong FOC full-text research papers are:-
1. https://www.ncbi.nlm.nih.gov/pmc/ [the PMC dataase on the National Library of Medicine website provides free .pdf docs for millions of research papers]

2. Google scholar search engine.

If you need any explanation of medical terminology/concepts, you know now where to find Sheldon!