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the building's structural system and whether it can support the required loads being placed on the structure (by the occupants, by the building itself, by the activities going on inside);
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window size and placement to provide enough natural light for the interior, and shading to reduce overheating/glare;
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ventilation requirements (and how you're going to achieve those - mechanical, natural or hybrid ventilation);
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acoustic requirements (sound isolation between rooms and storeys)
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thermal comfort (heating and cooling systems)
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fire safety and escape routes