Lucky we've got a pretty deep squad. I'd keep one of Rooney or Van Persie fresh for Chelsea along with Hernandez. Kagawa/Welbeck can partner the other for Sunderland. Then options on the wing with combinations involving Valencia, Young, Welbeck/Kagawa, Nani (hopefully).
Giggs, Anderson, Cleverly and Carrick for midfield. Evans, Smalling, Rio, Vidic at CB, and Rafael/Jones full back. I'd personally play Buttner against Sunderland, keep Evra for Chelsea.