100%, these are my GCSE grades:
English Literature 8
English Language 4
Double Science 8-7
Maths 8
French 7
Geography 7
Business 7
PE 6
These are one of my friends:
English Literature 5
English Language 5
Double Science 8-7
Maths 8
French 5
History (I can't remember but they either got a 5 or they failed)
Art 8
Tech 5
I've received offers from Manchester, Nottingham & Bath (not a RG but still a top 10 uni), and I'm waiting on Edinburgh & St Andrews (also not RG). My friend has offers from Cardiff, Sussex (not RG) and Nottingham and is waiting on Bristol and Warwick. GCSEs really don't matter much, you have good grades anyways. I stressed night after night over my English Language grade and whether I'd get rejected because of it. I was going to resit but in the end decided not to. I can see you're more of an essay subject person whereas I'm the opposite, so unless you're applying to unis where you need a minimum of a 6 in maths, you'll be absolutely fine.