My daughter is also applying for biomedical sciences. It is very oversubscribed, and for her option (neuroscience) they only give offers to 35% of Rest of the UK applicants. I think the broader biomedical sciences is the same. I agree, I can't see any reason why you would be rejected, but when we went to the open day they were pretty clear that the AAB offer is a minimum and heavily implied that applicants would need higher grades (possibly considerably higher grades?) to be considered. We had a chat with one of the lecturers about 2nd year entry. It is possible but far from guaranteed - it is competitive and there are only a limited number of spaces. Those who do go straight into 2nd year often struggle initially. Most will catch up and be fine, but it does tend to make for a stressful first year. We didn't ask what grades would be needed for 2nd year entry, but I suspect pretty high. After this conversation my daughter decided she would rather just go for 1st year entry and take the extra year, particularly as she would like to do a year abroad in her 3rd year.