The Open University tried to start a US arm (USOU) around the turn of the millenium, but it failed pretty badly. One of the problems that it had was that it had only probationary accreditation, and didn't survive long enough for full accreditation.
American employers typically take foreign degrees at face value, but there may be some difficulty with the Open University. There's a large number (or at least large marketing footprint) of for-profit private universities in the US which give distance learning in general a bad name. Add to this that the words "Open University" conjur up images of open source MOOC learning, and a lazy HR manager will possibly dismiss it out of hand without investigating the OU first. This will likely impact whether or not you get an interview.
If you do get an interview, all the places I've worked over there do proper research on candidate credentials before accepting or dismissing candidates based on those credentials. At that point, any credible employer won't hold your application in any lower esteem than any other university graduate.
If you're definitely looking to move to the US, it may be an idea to look at an established public US university with a strong (and affordable) distance learning branch.
Oregon State University or
Utah State University, for example, have fair programs, depending on your desired major, and fair tuition for international students.