Biology/Zoology at University of Bristol 2014

I think that this is probably best viewed as a 'risky' application, so you will need to have some other, lower grade, choices too. They'll look at both your AS grades and A2 predictions, but as both fall short I'd suggest that you will not be top of the pile. What grades do your other choices want?

Ask your referee to explain why they think that you will go up by two grades (e.g. you had mitigating circumstances) - a +1 prediction is entirely normal, but a +2 prediction can raise fears of an unachieveable prediction. In this case, if I was an admissions tutor, the first thing I'd think would be that you were predicted a B simply because that was more in line with your other AS grades, and it would make getting offers more likely, not because you actually have the inherent ability to go up to a B grade. If this is not the case, it should be explained in your reference.

Why is your predicted grade for French lower than your AS grade? That's very unusual.

All universities will look at both your achieved grades and your predicted grades. Bristol is a fairly competitive university anyway, so I think this is best considered a risky application.

I do think your referee should be justifying your unusual predicted grades. Is there a reason you only got a D in Biology AS?

Given your low AS grade for biology, you might be better reapplying on a gap year. I think the D at AS will raise some concerns and put you in a weaker position compared to other applicants.