Yes and no.
I can’t speak for anything outside of my own subject (Biomedical Science I.e I work in a hospital lab) but truth be told where I stand, your degree classification only exists in helping you obtain your first job. After that, experience is what matters (I graduated 5 years ago).
My history was I graduated in 2018 (with a 2.2 in an IBMS accredited degree) and went onto a teaching course, hated teaching and left vowing to never return after my first year.
After this, I got a job in one of the mass testing COVID labs as a Medical Lab Assistant and after 3 months, got promoted to an Associate Practitioner.
Stayed in that position for a year before Boris Johnson decided to close them down and 2 months later, the lab opens up again, just on a much smaller scale with 10% of its original capacity (had a capacity of 400 initially and was reduced to around 40), luckily I was one of those 40.
So overall after leaving in August 2023 to obtain my MSc in Biomedical Science (specialising in Clinical Biochemistry), I had accumulated around 3 years of in lab experience and have currently completed 2/3 of my IBMS portfolio (needed for Health and Professions Council Accreditation). I am also allowed back in the lab despite me not being employed there to continue to have pieces signed off.
Tl;dr - A masters can help nullify a 2.2 classification but after so long in industry, experience is king as someone with a first but fresh out of uni will be less desirable than someone with a 2.2 but with 3+ years experience.