Honestly had something like this with my girlfriend. Funnily enough, I didn't actually get a response on the first dating site we matched on. I had no problem getting dates with other girls, so if a girl didn't reply I didn't usually dwell on it, but she stayed on my mind. She was very much the girl next door, classically pretty, her bio felt real, and she was in the same field as me (life science). I'm very eccentric and dress like a punk so figured I just wasn't her type when I didn't get a reply. A month later I matched with her again on another dating site and after staring at her profile for a few mins decided to make a second attempt and surprisingly she accepted my invite to go for a pint. Fast forward a year (it is our anniversary next week) and we now live together and are in the process of buying our first house.
So, in a way, yes I suppose. Love might be too strong a word for it but I knew when I came across her profile that I just wanted to meet this woman. And halfway through our first date I knew she was the woman I wanted to be with. It took a little longer for her to be certain, but she's now just as committed as I am. Romance and lust are still as strong now as it was at the start - usually by this point I've lost interest if I'm being completely honest. I used to live for the thrill of the chase. Not anymore.
Oh, and the reason she didn't respond to my message on the first dating app? She'd uninstalled it and never saw it.
tl;dr - I felt this way with one specific girl on an app and a year later we are buying a house together. Go with your gut and see how it goes. I just asked my now girlfriend if she would like to meet at [pub near the location in her profile pic] for a drink with me and get to know each other in real life. That was literally the very first message - I didn't even say hi first. It worked out.